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Antimicrobial Agents and Chemotherapy, December 2005, p. 5162-5165, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5162-5165.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Assessing the In Vitro Effectiveness of Antimicrobials against Mycoplasma mycoides subsp. mycoides Small-Colony Type To Reduce Contagious Bovine Pleuropneumonia Infection

R. D. Ayling,1* S. Bisgaard-Frantzen,1 J. B. March,2 K. Godinho,3 and R. A. J. Nicholas1

Veterinary Laboratories Agency (Weybridge), Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom,1 Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 0PZ, United Kingdom,2 Pfizer Limited, Sandwich, Kent CT13 9NJ, United Kingdom3

Received 11 August 2005/ Returned for modification 17 September 2005/ Accepted 4 October 2005

In vitro minimum inhibitory concentrations were determined for 21 antimicrobials against 41 isolates of Mycoplasma mycoides subsp. mycoides small-colony type, the cause of contagious bovine pleuropneumonia. Of the antimicrobials used most widely in Africa, oxytetracycline and tilmicosin were effective, while the isolates were resistant to tylosin. These results provide a baseline for monitoring antimicrobial resistance.

* Corresponding author. Mailing address: Veterinary Laboratories Agency (Weybridge), Woodham Lane, Addlestone, Surrey KT15 3NB, United Kingdom. Phone: 44 (0) 1932 357616. Fax: 44 (0) 1932 357423. E-mail: r.d.ayling{at}vla.defra.gsi.gov.uk.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5162-5165, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5162-5165.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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