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Antimicrobial Agents and Chemotherapy, December 2005, p. 5166-5168, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5166-5168.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Synergy of Daptomycin plus Rifampin against Enterococcus faecium Resistant to both Linezolid and Vancomycin

George Pankey,* Deborah Ashcraft, and Nalini Patel

Ochsner Clinic Foundation, New Orleans, Louisiana

Received 20 May 2005/ Returned for modification 21 August 2005/ Accepted 27 September 2005

In vitro synergy testing of daptomycin plus rifampin was performed against 24 unique isolates of Enterococcus faecium resistant to both linezolid and vancomycin. Synergy testing showed that 21/24 (88%) were synergistic and 3/24 (12%) were indifferent by the Etest method. Time-kill assays revealed synergy for 18/24 (75%) and indifference for 6/24 (25%).

* Corresponding author. Mailing address: Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121. Phone: (504) 842-4006. Fax: (504) 842-5433. E-mail: gpankey{at}ochsner.org.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5166-5168, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5166-5168.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Steenbergen, J. N., Mohr, J. F., Thorne, G. M. (2009). Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studies. J Antimicrob Chemother 64: 1130-1138 [Abstract] [Full Text]  
  • Schutt, A. C, Bohm, N. M (2009). Multidrug-Resistant Enterococcus faecium Endocarditis Treated with Combination Tigecycline and High-Dose Daptomycin. The Annals of Pharmacotherapy 43: 2108-2112 [Abstract] [Full Text]  
  • Hassoun, A.A., Coomer, R.W., Mendez-Vigo, L. (2009). Intraperitoneal Daptomycin Used to Successfully Treat Vancomycin-Resistant Enterococcus Peritonitis. pdi 29: 671-673 [Full Text]  
  • Warren, R. E. (2008). Daptomycin in endocarditis and bacteraemia: a British perspective. J Antimicrob Chemother 62: iii25-iii33 [Abstract] [Full Text]  


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