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Antimicrobial Agents and Chemotherapy, December 2005, p. 5172-5175, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5172-5175.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Cloning and Functional Analysis of the Gene Encoding the 33- to 36-Kilodalton Outer Membrane Protein Associated with Carbapenem Resistance in Acinetobacter baumannii

Maria del Mar Tomás,1 Alejandro Beceiro,1 Astrid Pérez,1 David Velasco,1 Rita Moure,1 Rosa Villanueva,1 Jesús Martínez-Beltrán,2 and Germán Bou1*

Servicio de Microbiologia-Unidad de Investigacion, Complejo Hospitalario Universitario Juan Canalejo, 15006 La Coruña,1 Servicio de Microbiologia, Hospital Ramon y Cajal, 28034 Madrid, Spain2

Received 21 June 2005/ Returned for modification 9 August 2005/ Accepted 16 September 2005

We investigated a multiresistant strain of Acinetobacter baumannii isolated in our hospital. Analysis of the N-terminal peptide sequence of the outer membrane proteins (OMPs) purified from the strain allowed us to clone and sequence the nucleotides of the gene encoding the 33- to 36-kDa OMP associated with carbapenem resistance in A. baumannii

* Corresponding author. Mailing address: Servicio de Microbiologia-Unidad de Investigacion, Complejo Hospitalario Universitario Juan Canalejo, As Xubias, 84, 15006 La Coruña, Spain. Phone: 34-981178359. Fax: 34-981178216. E-mail: germanbou{at}canalejo.org.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5172-5175, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5172-5175.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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