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Antimicrobial Agents and Chemotherapy, December 2005, p. 5176-5178, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5176-5178.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

High Rate of Resistance to Quinupristin-Dalfopristin in Enterococcus faecium Clinical Isolates from Korea

Won Sup Oh,^1, Kwan Soo Ko,^1,2, Jae-Hoon Song,^1,2* Mi Young Lee,² Sulhee Park,² Kyong Ran Peck,¹ Nam Yong Lee,³ Choon-Kwan Kim,⁴ Hyuck Lee,⁵ Shin-Woo Kim,⁶ Hyun-Ha Chang,⁶ Yeon-Sook Kim,⁷ Sook-In Jung,⁸ Jun Seong Son,⁹ Joon-Sup Yeom,¹⁰ Hyun Kyun Ki,¹¹ and Gun-Jo Woo¹²

Division of Infectious Diseases,¹ Department of Laboratory Medicine, Samsung Medical Center, Seoul,³ Kangbuk Samsung Hospital, Seoul,¹⁰ Sungkyunkwan University School of Medicine, Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul,² Seoul Veterans Hospital, Seoul,⁴ Dong-A University Hospital, Busan,⁵ Kyungpook National University Hospital, Daegu,⁶ Chungnam National University Hospital, Daejeon,⁷ Chonnam National University Medical School, Gwangju,⁸ Chungbuk National University Hospital, Chungju,⁹ Konkuk University Hospital, Seoul,¹¹ Division of Food Microbiology, Korean Food & Drug Administration, Seoul, Korea,¹²

Received 14 July 2005/ Returned for modification 19 August 2005/ Accepted 20 September 2005

We tested the in vitro susceptibilities of 603 enterococcal isolates from eight tertiary-care hospitals in Korea. The quinupristin-dalfopristin resistance rate in Enterococcus faecium was very high (25 isolates, 10.0%). It was suggested that both clonal spread and the sporadic emergence of quinupristin-dalfopristin-resistant isolates may explain the high prevalence of quinupristin-dalfopristin resistance in Korea.

W.S.O and K.S.K. contributed equally as joint first authors.

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