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Antimicrobial Agents and Chemotherapy, December 2005, p. 5182-5184, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5182-5184.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antipneumococcal Activity of Dalbavancin Compared to Other Agents

Gengrong Lin, Kathy Smith, Lois M. Ednie, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 19 July 2005/ Returned for modification 12 September 2005/ Accepted 23 September 2005

Against 307 pneumococci of various resistotypes, dalbavancin MICs were 0.008 to 0.125 µg/ml. All strains were susceptible to vancomycin, teicoplanin, linezolid, and quinupristin-dalfopristin. Dalbavancin at 2x MIC was bactericidal against all 10 pneumococci tested after 24 h. Vancomycin and teicoplanin killed 10 and 8 strains, respectively, at 2x MIC after 24 h.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5182-5184, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5182-5184.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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