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Antimicrobial Agents and Chemotherapy, February 2005, p. 767-769, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.767-769.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Multiechinocandin- and Multiazole-Resistant Candida parapsilosis Isolates Serially Obtained during Therapy for Prosthetic Valve Endocarditis

Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan

Received 13 May 2004/ Returned for modification 5 August 2004/ Accepted 21 October 2004

Echinocandins are approved for the treatment of candidal infections. In vitro they have been shown to be less potent against strains of Candida parapsilosis than against other Candida spp. This is the first case report describing the development of a secondary multidrug (echinocandin-azole)-resistant Candida strain during therapy.

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