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Antimicrobial Agents and Chemotherapy, February 2005, p. 770-772, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.770-772.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antistaphylococcal Activity of Dalbavancin, an Experimental Glycopeptide

Gengrong Lin, Kim Credito, Lois M. Ednie, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania

Received 11 June 2004/ Returned for modification 23 September 2004/ Accepted 11 October 2004

Dalbavancin, tested against 146 staphylococci, was more potent than other drugs tested, with an MIC at which 50% of staphylococci were inhibited of 0.03 µg/ml and an MIC at which 90% of staphylococci were inhibited of 0.06 µg/ml by microdilution. For all strains, MICs of vancomycin, linezolid, ranbezolid, oritavancin, daptomycin, and quinupristin-dalfopristin were ≤4.0 µg/ml. Dalbavancin was bactericidal at four times the MIC against all six strains tested.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, February 2005, p. 770-772, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.770-772.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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