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Antimicrobial Agents and Chemotherapy, February 2005, p. 781-782, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.781-782.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Biocide Triclosan Selects Stenotrophomonas maltophilia Mutants That Overproduce the SmeDEF Multidrug Efflux Pump

Patricia Sanchez, Eduardo Moreno, and Jose L. Martinez*

Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain

Received 28 May 2004/ Returned for modification 8 August 2004/ Accepted 7 October 2004

The possibility that triclosan selects Stenotrophomonas maltophilia mutants overexpressing the multidrug resistance pump SmeDEF is analyzed. Five out of 12 triclosan-selected mutants were less susceptible to antibiotics than the wild-type strain and overproduced SmeDEF. Results are discussed in relation to current debates on the potential selection of antibiotic-resistant bacteria by household biocides.

* Corresponding author. Mailing address: Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. Phone: 34-91-5854542. Fax: 34-91-5854506. E-mail: jlmtnez{at}cnb.uam.es.

Antimicrobial Agents and Chemotherapy, February 2005, p. 781-782, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.781-782.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Martinez, J. L. (2009). The role of natural environments in the evolution of resistance traits in pathogenic bacteria. Proc R Soc B 276: 2521-2530 [Abstract] [Full Text]  
  • Hernandez, A., Mate, M. J., Sanchez-Diaz, P. C., Romero, A., Rojo, F., Martinez, J. L. (2009). Structural and Functional Analysis of SmeT, the Repressor of the Stenotrophomonas maltophilia Multidrug Efflux Pump SmeDEF. J. Biol. Chem. 284: 14428-14438 [Abstract] [Full Text]  
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  • Mima, T., Joshi, S., Gomez-Escalada, M., Schweizer, H. P. (2007). Identification and Characterization of TriABC-OpmH, a Triclosan Efflux Pump of Pseudomonas aeruginosa Requiring Two Membrane Fusion Proteins. J. Bacteriol. 189: 7600-7609 [Abstract] [Full Text]  
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  • Piddock, L. J. V. (2006). Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria. Clin. Microbiol. Rev. 19: 382-402 [Abstract] [Full Text]  
  • Poole, K. (2005). Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56: 20-51 [Abstract] [Full Text]  


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