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Antimicrobial Agents and Chemotherapy, February 2005, p. 781-782, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.781-782.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Biocide Triclosan Selects Stenotrophomonas maltophilia Mutants That Overproduce the SmeDEF Multidrug Efflux Pump

Patricia Sanchez, Eduardo Moreno, and Jose L. Martinez*

Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain

Received 28 May 2004/ Returned for modification 8 August 2004/ Accepted 7 October 2004

The possibility that triclosan selects Stenotrophomonas maltophilia mutants overexpressing the multidrug resistance pump SmeDEF is analyzed. Five out of 12 triclosan-selected mutants were less susceptible to antibiotics than the wild-type strain and overproduced SmeDEF. Results are discussed in relation to current debates on the potential selection of antibiotic-resistant bacteria by household biocides.

* Corresponding author. Mailing address: Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. Phone: 34-91-5854542. Fax: 34-91-5854506. E-mail: jlmtnez{at}cnb.uam.es.

Antimicrobial Agents and Chemotherapy, February 2005, p. 781-782, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.781-782.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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