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Antimicrobial Agents and Chemotherapy, February 2005, p. 783-787, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.783-787.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Rapid Acquisition of Stable Azole Resistance by Candida glabrata Isolates Obtained before the Clinical Introduction of Fluconazole

Annemarie Borst, Maria T. Raimer, David W. Warnock, Christine J. Morrison, and Beth A. Arthington-Skaggs*

Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Received 19 August 2004/ Returned for modification 16 September 2004/ Accepted 8 October 2004

Five azole-susceptible Candida glabrata isolates obtained before 1975 became resistant to fluconazole, itraconazole, and voriconazole within 4 days of in vitro fluconazole exposure. This cross-resistance was stable for at least 4 months after removal of fluconazole and was associated with increased CgCDR1 and CgCDR2 expression.

* Corresponding author. Mailing address: Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., N.E., Mailstop G-11, Atlanta, GA 30333. Phone: (404) 639-4041. Fax: (404) 639-3546. E-mail: BSkaggs{at}cdc.gov.

Antimicrobial Agents and Chemotherapy, February 2005, p. 783-787, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.783-787.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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