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Antimicrobial Agents and Chemotherapy, February 2005, p. 791-793, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.791-793.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

AcrAB Efflux Pump Plays a Role in Decreased Susceptibility to Tigecycline in Morganella morganii

Alexey Ruzin,* David Keeney, and Patricia A. Bradford

Wyeth Research, Pearl River, New York

Received 30 June 2004/ Returned for modification 1 September 2004/ Accepted 7 October 2004

Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 µg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 µg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux pump in decreased susceptibility to tigecycline in M. morganii.

* Corresponding author. Mailing address: Wyeth Research, Department of Infectious Disease, 401 North Middletown Rd., Bld. 200, Rm. 3219, Pearl River, NY 10965. Phone: (845) 602-4592. Fax: (845) 602-5671. E-mail: ruzina{at}wyeth.com.

Antimicrobial Agents and Chemotherapy, February 2005, p. 791-793, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.791-793.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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