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Antimicrobial Agents and Chemotherapy, February 2005, p. 794-797, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.794-797.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The aadB Gene Cassette Is Associated with blaSHV Genes in Klebsiella Species Producing Extended-Spectrum ß-Lactamases

Louisa A. Jones,1,2 Christopher J. McIver,1,2,3 Mi-Jurng Kim,2 William D. Rawlinson,1,2,3 and Peter A. White1,2*

School of Biotechnology and Biomolecular Sciences, Faculty of Science,2 School of Medical Sciences, Faculty of Medicine, the University of New South Wales,3 Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia1

Received 30 March 2004/ Returned for modification 26 June 2004/ Accepted 25 October 2004

Integrons were detected in 37 (72.5%) of 51 Klebsiella spp. producing extended-spectrum beta-lactamases by PCR with primers that targeted integrase genes and cassette regions. PCR and amplicon sequencing of the cassette regions revealed aadB and aadA2 gene cassettes that confer resistance to a range of aminoglycosides. aadB was associated with a class 1 integron on a 28-kb plasmid, pES1, that also contained blaSHV-12 and IS26.

* Corresponding author. Mailing address: School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney 2052, Australia. Phone: 61 9385 3780. Fax: 61 9385 1591. E-mail: p.white{at}unsw.edu.au.

Antimicrobial Agents and Chemotherapy, February 2005, p. 794-797, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.794-797.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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