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Antimicrobial Agents and Chemotherapy, February 2005, p. 798-800, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.798-800.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Test Characteristics of Perirectal and Rectal Swab Compared to Stool Sample for Detection of Fluoroquinolone-Resistant Escherichia coli in the Gastrointestinal Tract

Ebbing Lautenbach,^1,2,3,4* Anthony D. Harris,^5,6 Eli N. Perencevich,^5,6 Irving Nachamkin,⁷ Pam Tolomeo,³ and Joshua P. Metlay^2,3,4,8,9

Divisions of Infectious Diseases,¹ General Internal Medicine, Department of Medicine,⁸ Department of Biostatistics and Epidemiology,² Department of Pathology and Laboratory Medicine,⁷ Center for Clinical Epidemiology and Biostatistics,³ Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine,⁴ Department of Veterans Affairs, Philadelphia, Pennsylvania,⁹ Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine,⁵ Veterans Affairs Maryland Health Care System, Baltimore, Maryland⁶

Received 17 September 2004/ Returned for modification 19 October 2004/ Accepted 23 October 2004

Among 63 patients enrolled in a prospective cohort study of gut colonization with fluoroquinolone-resistant Escherichia coli, the sensitivity of perirectal swab compared to stool sample was 90% (95% confidence interval [CI], 70 to 99%) and the specificity was 100% (95% CI, 91 to 100%). For rectal swab, the sensitivity was 90% (95% CI, 68 to 99%) and the specificity was 100% (95% CI, 91 to 100%).

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* Corresponding author. Mailing address: University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Dr., Philadelphia, PA 19104-6021. Phone: (215) 898-6977. Fax: (215) 573-5315. E-mail: elautenb{at}cceb.med.upenn.edu.

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Antimicrobial Agents and Chemotherapy, February 2005, p. 798-800, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.798-800.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

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