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Antimicrobial Agents and Chemotherapy, February 2005, p. 824-826, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.824-826.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Elucidation of Essential and Nonessential Genes in the Haemophilus influenzae Rd Cell Wall Biosynthetic Pathway by Targeted Gene Disruption

Catherine M. Trepod1* and John E. Mott2

Antibacterials, Pfizer Inc., Groton, Connecticut,1 Global Biologics, Pfizer Inc., Chesterfield, Missouri2

Received 19 April 2004/ Returned for modification 25 April 2004/ Accepted 3 October 2004

Targeted gene disruption by in vitro transposon mutagenesis has been used to identify the genes required for biosynthesis of the Haemophilus influenzae Rd cell wall under standard cultivation conditions. Of the 28 genes known to be associated with the cell wall biosynthetic pathway, 14 were determined to be essential.

* Corresponding author. Mailing address: Pfizer Global R&D, MS8220-2343, Eastern Point Rd., Groton, CT 06340. Phone: (860) 686-6810. Fax: (860) 715-4693. E-mail: catherine.m.trepod{at}pfizer.com.

Antimicrobial Agents and Chemotherapy, February 2005, p. 824-826, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.824-826.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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