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Antimicrobial Agents and Chemotherapy, February 2005, p. 840-842, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.840-842.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mutations in pfmdr1 Modulate the Sensitivity of Plasmodium falciparum to the Intrinsic Antiplasmodial Activity of Verapamil

School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, Australia

Received 26 August 2004/ Returned for modification 4 October 2004/ Accepted 21 October 2004

As well as having the ability to reverse chloroquine resistance in the human malaria parasite Plasmodium falciparum, verapamil has itself an innate antiplasmodial activity. We show here that mutations in Pgh1, the product of the malaria parasite's pfmdr1 gene, influence the parasite's susceptibility to the toxic effects of verapamil.

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