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Antimicrobial Agents and Chemotherapy, February 2005, p. 843-845, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.843-845.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effects of Cetylpyridinium Chloride Resistance and Treatment on Fluconazole Activity versus Candida albicans

Merritt P. Edlind, W. Lamar Smith, and Thomas D. Edlind*

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania

Received 11 August 2004/ Returned for modification 20 September 2004/ Accepted 6 October 2004

Mouthwash antiseptic cetylpyridinium chloride (CPC) has potent activity against Candida albicans; however, two of five azole-resistant strains showed reduced CPC susceptibility. To further examine the potential for cross-resistance, CPC-resistant mutants were selected in vitro and their fluconazole susceptibility was tested. MICs were unchanged, and trailing growth generally decreased. With CPC-fluconazole combinations, both antagonism and synergism were observed, which can be explained, in part, by CDR1-CDR2 multidrug transporter upregulation.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Drexel University of College of Medicine, 2900 Queen Ln., Philadelphia, PA 19129. Phone: (215) 991-8377. Fax: (215) 848-2271. E-mail: tedlind{at}drexelmed.edu.

Antimicrobial Agents and Chemotherapy, February 2005, p. 843-845, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.843-845.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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