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Antimicrobial Agents and Chemotherapy, February 2005, p. 846-848, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.846-848.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Stability of Fluoroquinolone Resistance in Streptococcus pneumoniae Clinical Isolates and Laboratory-Derived Mutants

Heather J. Smith-Adam,1* Kimberly A. Nichol,2 Daryl J. Hoban,1,2 and George G. Zhanel1,2,3

Department of Medical Microbiology, Faculty of Medicine, University of Manitoba,1 Departments of Medicine,3 Clinical Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada2

Received 26 September 2004/ Accepted 21 October 2004

The stability of fluoroquinolone resistance in Streptococcus pneumoniae was evaluated in laboratory-derived mutants and clinical isolates. Isolates with various genotypes and phenotypes were subcultured for 20 days on antibiotic-free media and were monitored by E-tests to identify any alterations in resistance. Fluoroquinolone resistance mechanisms, whether efflux or chromosomally mediated, remained stable in both clinical and laboratory-derived mutants.

* Corresponding author. Mailing address: Clinical Microbiology, Health Sciences Centre, MS673-820 Sherbrook St., Winnipeg, Manitoba, R3A 1R9 Canada. Phone: (204) 787-4684. Fax: (204) 787-4699. E-mail: smithhj14{at}hotmail.com.

Antimicrobial Agents and Chemotherapy, February 2005, p. 846-848, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.846-848.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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