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Antimicrobial Agents and Chemotherapy, February 2005, p. 857-859, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.857-859.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Activity of Glycopeptides against Staphylococcus aureus Infection in a Rabbit Endocarditis Model: MICs Do Not Predict In Vivo Efficacy

Laboratoire Antibiologie, UPRES EA 3826, Nantes, France

Received 16 June 2004/ Returned for modification 25 July 2004/ Accepted 27 September 2004

The in vivo efficacy of vancomycin and teicoplanin against five Staphylococcus aureus strains with different susceptibilities to them and methicillin was studied. Rabbits were allocated at random to groups for endocarditis induction with one of these five strains and then treated for 2 days with vancomycin or teicoplanin. Each treated group was compared with a control group infected with the same strain. Vancomycin and teicoplanin showed similar activities. Low MICs did not predict better in vivo results.

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