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Antimicrobial Agents and Chemotherapy, March 2005, p. 1181-1183, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1181-1183.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Efficacy and Toxicity of Zinc Salts as Candidate Topical Microbicides against Vaginal Herpes Simplex Virus Type 2 Infection

Nigel Bourne,1* Rachael Stegall,1 Raquel Montano,1 Michael Meador,1 Lawrence R. Stanberry,1 and Gregg N. Milligan1

Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas1

Received 5 August 2004/ Returned for modification 8 November 2004/ Accepted 19 November 2004

Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These observations limit the utility of zinc salts as microbicides and suggest that the application of zinc solutions to mucosal surfaces has the potential to cause damage that might increase susceptibility to secondary infections at a later time.

* Corresponding author. Mailing address: Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd., Galveston, Texas, 77555-0436. Phone: (409) 747-8140. Fax: (409) 747-8150. E-mail: nibourne{at}utmb.edu.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1181-1183, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1181-1183.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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