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Antimicrobial Agents and Chemotherapy, March 2005, p. 1184-1189, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1184-1189.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Novel Engineered Peptide, a Narrow-Spectrum Antibiotic, is Effective against Vancomycin-Resistant Enterococcus faecalis

Xiao-Qing Qiu,1 Jie Zhang,1 He Wang,2 and George Y. Wu3*

Laboratory of Biomembrane and Membrane Protein, West China Hospital,1 Laboratory of Genetics, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China,2 Division of Gastroenterology-Hepatology, Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut3

Received 2 September 2004/ Returned for modification 23 October 2004/ Accepted 5 November 2004

A novel antienterococcal peptide was prepared by fusing the enterococcal cCF10 pheromone to the channel-forming domain of colicin Ia, forming Enterococcus faecalis pheromonicin (PMC-EF). This peptide was bactericidal against vancomycin-resistant Enterococcus faecalis (VRE) organisms. Electron microscopy and vital dyes confirmed increased membrane permeability. All mice made bacteremic with VRE strains survived when they were treated with PMC-EF, while all controls died.

* Corresponding author. Mailing address: Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Rm. AM-044, 263 Farmington Ave., Farmington, CT 06030-1845. Phone: (860) 679-3158. Fax: (860) 679-3159. E-mail: wu{at}nso.uchc.edu.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1184-1189, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1184-1189.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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