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Antimicrobial Agents and Chemotherapy, March 2005, p. 1190-1193, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1190-1193.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Development of Resistance to Six and Four Fluoroquinolones in Mycoplasma pneumoniae and Mycoplasma hominis, Respectively

D. Gruson,1 S. Pereyre,1 H. Renaudin,1 A. Charron,1 C. Bébéar,1 and C. M. Bébéar1*

Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, Bordeaux, France1

Received 30 July 2004/ Returned for modification 13 October 2004/ Accepted 9 November 2004

Selection of resistant mutants in sequential subcultures with increasing concentrations of six and four different fluoroquinolones was studied for one reference strain each of Mycoplasma pneumoniae and Mycoplasma hominis, respectively. All fluoroquinolones tested selected for resistance, with alterations affecting the quinolone resistance-determining regions of the four target topoisomerase genes.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Phone: (33) 5 57 57 16 25. Fax: (33) 5 56 93 29 40. E-mail: cecile.bebear{at}u-bordeaux2.fr.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1190-1193, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1190-1193.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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