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Antimicrobial Agents and Chemotherapy, March 2005, p. 1194-1197, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1194-1197.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Integrons and Transposons on the Salmonella enterica Serovar Typhimurium Virulence Plasmid

Laura Villa1 and Alessandra Carattoli1*

Department of Infectious, Parasitic, and Immuno-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy1

Received 15 June 2004/ Returned for modification 2 September 2004/ Accepted 5 November 2004

A virulence plasmid was identified in a multidrug-resistant Salmonella enterica serotype Typhimurium strain carrying the spvC, rck, and pefA virulence genes and two class 1 integrons linked to the Tn21 and Tn1696 transposons. A novel trimethoprim resistance gene, designated dfrA23, was also identified within the integron region. The association of multidrug resistance and virulence determinants represents an interesting example of virulence plasmid evolution.

* Corresponding author. Mailing address: Department of Infectious, Parasitic, and Immuno-mediated Disease, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39-06-49903128. Fax: 39-06-49387112. E-mail: alecara{at}iss.it.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1194-1197, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1194-1197.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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