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Antimicrobial Agents and Chemotherapy, March 2005, p. 1209-1212, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1209-1212.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Inhaled Nitric Oxide Treatment of Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears

Richard Long,1* Richard Jones,1 James Talbot,2 Irvin Mayers,1 James Barrie,3 Michael Hoskinson,3 and Bruce Light4

Departments of Medicine,1 Medical Microbiology and Immunology,2 Radiology, University of Alberta, Edmonton,3 the Department of Medicine, University of Manitoba, Winnipeg, Canada4

Received 11 August 2004/ Returned for modification 7 October 2004/ Accepted 21 October 2004

Endogenous nitric oxide (NO) has antimycobacterial properties. We tested the hypothesis that exogenous (inhaled) NO can be safely delivered and can accelerate airway disinfection for pulmonary tuberculosis patients treated with standard therapy. Exogenous NO administered at 80 ppm for 72 h can be safely delivered but does not accelerate airway disinfection.

* Corresponding author. Mailing address: Department of Medicine, University of Alberta, Room 8325, Aberhart Centre 1, 11402, University Ave., Edmonton, Alberta T6G 2J3, Canada. Phone: (780) 407-1427. Fax: (780) 407-1429. E-mail: richard.long{at}ualberta.ca.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1209-1212, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1209-1212.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mannick, J. B. (2006). Immunoregulatory and antimicrobial effects of nitrogen oxides.. Proc Am Thorac Soc 3: 161-165 [Abstract] [Full Text]  


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