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Antimicrobial Agents and Chemotherapy, March 2005, p. 1213-1215, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1213-1215.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Efg1 Involved in Drug Resistance by Regulating the Expression of ERG3 in Candida albicans

Hsiu-Jung Lo,1 Jang-Shiun Wang,1,2 Chih-Yang Lin,3 Chia-Geun Chen,1,2 Ting-Yin Hsiao,4 Chia-Tung Hsu,4 Chia-Li Su,1 Ming-Ji Fann,5 Yu-Tai Ching,3 and Yun-Liang Yang4*

Division of Clinical Research, National Health Research Institutes,1 Graduate Institute of Life Sciences, National Defense Medical Center,2 Institute for Neuroscience, School of Life Sciences, National Yang-Ming University, Taipei,5 Department of Computer and Information Science,3 Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, Republic of China4

Received 6 October 2004/ Returned for modification 26 October 2004/ Accepted 14 November 2004

The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.

* Corresponding author. Mailing address: Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, Republic of China. Phone: (03) 5712-121, ext. 56920. Fax: (03) 5729-288. E-mail: yyang{at}mail.nctu.edu.tw.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1213-1215, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1213-1215.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Biswas, S., Van Dijck, P., Datta, A. (2007). Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans. Microbiol. Mol. Biol. Rev. 71: 348-376 [Abstract] [Full Text]  


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