This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Knobloch, J. K.-M. Articles by Mack, D. Search for Related Content PubMed PubMed Citation Articles by Knobloch, J. K.-M. Articles by Mack, D.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, March 2005, p. 1216-1219, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1216-1219.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

mecA Is Not Involved in the ^B-Dependent Switch of the Expression Phenotype of Methicillin Resistance in Staphylococcus epidermidis

Universitätsklinikum Hamburg-Eppendorf, Zentrum für Klinisch-Theoretische Medizin, Institut für Infektionsmedizin, Hamburg, Germany¹

Received 21 May 2004/ Returned for modification 11 August 2004/ Accepted 7 November 2004

A lack of ^B activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a ^B-negative strain. However, mecA is not involved in the switch of expression phenotype.

Present address: Medical Microbiology and Infectious Diseases, The Clinical School, University of Wales Swansea, Swansea SA2 8PP, United Kingdom.

This article has been cited by other articles:

• Jager, S., Mack, D., Rohde, H., Horstkotte, M. A., Knobloch, J. K.-M. (2005). Disintegration of Staphylococcus epidermidis Biofilms under Glucose-Limiting Conditions Depends on the Activity of the Alternative Sigma Factor {sigma}B. Appl. Environ. Microbiol. 71: 5577-5581 [Abstract] [Full Text]