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Antimicrobial Agents and Chemotherapy, March 2005, p. 1216-1219, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1216-1219.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

mecA Is Not Involved in the {sigma}B-Dependent Switch of the Expression Phenotype of Methicillin Resistance in Staphylococcus epidermidis

Johannes K.-M. Knobloch,1* Sebastian Jäger,1 Jörn Huck,1 Matthias A. Horstkotte,1 and Dietrich Mack1

Universitätsklinikum Hamburg-Eppendorf, Zentrum für Klinisch-Theoretische Medizin, Institut für Infektionsmedizin, Hamburg, Germany1

Received 21 May 2004/ Returned for modification 11 August 2004/ Accepted 7 November 2004

A lack of {sigma}B activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a {sigma}B-negative strain. However, mecA is not involved in the switch of expression phenotype.

* Corresponding author. Mailing address: Universitätsklinikum Hamburg-Eppendorf, Zentrum für Klinisch-Theoretische Medizin, Institut für Infektionsmedizin, Martinistr. 52, D-20246 Hamburg, Germany. Phone: 49 40 42803 3147. Fax: 49 40 42803 4881. E-mail: knobloch{at}uke.uni-hamburg.de.

{dagger} Present address: Medical Microbiology and Infectious Diseases, The Clinical School, University of Wales Swansea, Swansea SA2 8PP, United Kingdom.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1216-1219, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1216-1219.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jager, S., Mack, D., Rohde, H., Horstkotte, M. A., Knobloch, J. K.-M. (2005). Disintegration of Staphylococcus epidermidis Biofilms under Glucose-Limiting Conditions Depends on the Activity of the Alternative Sigma Factor {sigma}B. Appl. Environ. Microbiol. 71: 5577-5581 [Abstract] [Full Text]  


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