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Antimicrobial Agents and Chemotherapy, March 2005, p. 1225-1228, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1225-1228.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Synergistic Killing of Streptococcus pneumoniae with the Bacteriophage Lytic Enzyme Cpl-1 and Penicillin or Gentamicin Depends on the Level of Penicillin Resistance

Svetolik Djurkovic,1,2 Jutta M. Loeffler,1 and Vincent A. Fischetti1*

Laboratory of Bacterial Pathogenesis, The Rockefeller University,1 Sloan Kettering Cancer Institute, Division of Infectious Disease, New York, New York2

Received 4 June 2004/ Returned for modification 22 August 2004/ Accepted 29 October 2004

A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.

* Corresponding author. Mailing address: Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Ave., New York, NY 10021. Phone: (212) 327 8166. E-mail: vaf{at}rockefeller.edu.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1225-1228, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1225-1228.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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