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Antimicrobial Agents and Chemotherapy, March 2005, p. 1229-1231, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1229-1231.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Disequilibrium in Distribution of Resistance Mutations among Mycobacterium tuberculosis Beijing and Non-Beijing Strains Isolated from Patients in Germany

National Reference Center for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany¹

Received 25 August 2004/ Returned for modification 21 September 2004/ Accepted 26 October 2004

Genotypic analysis of 103 multidrug-resistant Mycobacterium tuberculosis strains isolated in Germany in 2001 revealed that mutations in codon 531 (75.7%) of the rpoB gene and codon 315 (88.4%) of the katG gene are most frequent. Beijing genotype strains (60.2% of all isolates) displayed a different distribution of resistance mutations than non-Beijing strains.

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