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Antimicrobial Agents and Chemotherapy, March 2005, p. 1232-1235, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1232-1235.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Combined Activity In Vitro of Caspofungin, Amphotericin B, and Azole Agents against Itraconazole-Resistant Clinical Isolates of Aspergillus fumigatus

Manuel Cuenca-Estrella,1* Alicia Gomez-Lopez,1 Guillermo Garcia-Effron,1 Laura Alcazar-Fuoli,1 Emilia Mellado,1 Maria J. Buitrago,1 and Juan L. Rodriguez-Tudela1

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain1

Received 16 July 2004/ Returned for modification 15 September 2004/ Accepted 21 November 2004

Interactions in vitro between amphotericin B, itraconazole, voriconazole, and caspofungin against itraconazole-resistant Aspergillus fumigatus clinical strains were determined. Differential results were obtained depending on the criteria (MIC or minimal effective concentration) used. Caspofungin and voriconazole exhibited the most potent interactions, with synergy against at least 50% of isolates, and the average fractional concentration index was 0.38. Antagonism was not found for any combination.

* Corresponding author. Mailing address: Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2. 28220 Majadahonda (Madrid), Spain. Phone: 34-91-5097961. Fax: 34-91-5097966. E-mail: mcuenca-estrella{at}isciii.es.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1232-1235, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1232-1235.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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