AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moore, J. M.
Right arrow Articles by Salama, N. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moore, J. M.
Right arrow Articles by Salama, N. R.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, March 2005, p. 1236-1237, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1236-1237.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mutational Analysis of Metronidazole Resistance in Helicobacter pylori

Jill M. Moore1 and Nina R. Salama1*

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington1

Received 12 September 2004/ Returned for modification 6 October 2004/ Accepted 11 November 2004

Metronidazole is one of a few antibiotics effective in eliminating Helicobacter pylori infection of the human stomach. Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance.

* Corresponding author. Mailing address: Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Mailstop C3-168, P.O. Box 19024, Seattle WA 98109-1024. Phone: (206) 667-1540. Fax: (206) 667-6524. E-mail: nsalama{at}fhcrc.org.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1236-1237, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1236-1237.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2005 by the American Society for Microbiology. All rights reserved.