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Antimicrobial Agents and Chemotherapy, March 2005, p. 1238-1241, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1238-1241.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

New Integron-Associated Gene Cassette Encoding a 3-N-Aminoglycoside Acetyltransferase

Department of Biological Sciences, Macquarie University, Sydney,³ School of Molecular and Microbial Biosciences, The University of Sydney, Sydney,⁵ New South Wales Department of Primary Industries, Microbiology and Immunology Section, Elizabeth Macarthur Agricultural Institute, Camden,¹ Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales,² Microbiological Diagnostic Unit, Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia⁴

Received 14 July 2004/ Returned for modification 29 August 2004/ Accepted 7 November 2004

A fifth gene cassette containing an aacC gene, aacCA5, was found in an aacCA5-aadA7 cassette array in a class 1 integron isolated from a multiply drug resistant Salmonella enterica serovar Kentucky strain. The AacC-A5 or AAC(3)-Ie acetyltransferase encoded by aacCA5 is related to other AAC(3)-I enzymes and confers resistance to gentamicin.

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