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Antimicrobial Agents and Chemotherapy, March 2005, p. 1242-1244, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1242-1244.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Experimental Prediction of the Evolution of Ceftazidime Resistance in the CTX-M-2 Extended-Spectrum Beta-Lactamase

Kerry J. Welsh,1 Miriam Barlow,1* Fred C. Tenover,2 James W. Biddle,2 J. Kamile Rasheed,2 Leigh Ann Clark,1 and John E. McGowan Jr.1

Department of Epidemiology, Rollins School of Public Health, Emory University,1 Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia2

Received 30 June 2004/ Returned for modification 26 September 2004/ Accepted 7 November 2004

We applied in vitro evolution to an Escherichia coli strain containing blaCTX-M-2 and obtained 10 independent mutant blaCTX-M-2 alleles that confer elevated resistance to ceftazidime (MIC ≥ 32 µg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at position 167.

* Corresponding author. Mailing address: Department of Epidemiology, Emory University, 1518 Clifton Rd., Rm. L-21, Atlanta, GA 30322. Phone: (404) 727-3042. Fax: (404) 727-8737. E-mail: mbarlow{at}sph.emory.edu.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1242-1244, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1242-1244.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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