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Antimicrobial Agents and Chemotherapy, March 2005, p. 1245-1248, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1245-1248.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Susceptibility of Streptococcus mutans and Actinobacillus actinomycetemcomitans to Bactericidal Activity of Human ß-Defensin 3 in Biological Fluids

Giuseppantonio Maisetta,1 Giovanna Batoni,1* Semih Esin,1 Giorgio Raco,1 Daria Bottai,1 Flavia Favilli,1 Walter Florio,1 and Mario Campa1

Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy1

Received 4 August 2004/ Returned for modification 2 September 2004/ Accepted 9 November 2004

Bactericidal activity of human ß-defensin 3 (hBD-3) against Streptococcus mutans and Actinobacillus actinomycetemcomitans was inhibited in a dose-dependent manner by the presence of saliva and/or serum. Increasing the concentration of hBD-3 partially overcame this inhibition. A fast bactericidal effect was observed against both bacterial strains, suggesting a potential therapeutic use for hBD-3 in the local treatment of oral infections.

* Corresponding author. Mailing address: Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Via San Zeno 35-39, 56127 Pisa, Italy. Phone: 39-050-2213694. Fax: 39-050-2213711. E-mail: batoni{at}biomed.unipi.it.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1245-1248, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1245-1248.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vylkova, S., Nayyar, N., Li, W., Edgerton, M. (2007). Human {beta}-Defensins Kill Candida albicans in an Energy-Dependent and Salt-Sensitive Manner without Causing Membrane Disruption. Antimicrob. Agents Chemother. 51: 154-161 [Abstract] [Full Text]  
  • Maisetta, G., Batoni, G., Esin, S., Florio, W., Bottai, D., Favilli, F., Campa, M. (2006). In Vitro Bactericidal Activity of Human {beta}-Defensin 3 against Multidrug-Resistant Nosocomial Strains. Antimicrob. Agents Chemother. 50: 806-809 [Abstract] [Full Text]  


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