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Antimicrobial Agents and Chemotherapy, March 2005, p. 1249-1252, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1249-1252.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of the Histatin Derivative P-113 against Multidrug-Resistant Pathogens Responsible for Pneumonia in Immunocompromised Patients

Andrea Giacometti,^1* Oscar Cirioni,¹ Wojciech Kamysz,² Giuseppina D'Amato,¹ Carmela Silvestri,¹ Maria Simona Del Prete,¹ Alberto Licci,¹ Alessandra Riva,¹ Jerzy ukasiak,² and Giorgio Scalise¹

Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy,¹ Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland²

Received 21 July 2004/ Returned for modification 27 April 2004/ Accepted 15 November 2004

The in vitro activity of the histatin derivative P-113, alone or combined with eight antibiotics, was investigated against multidrug-resistant strains isolated from clinical specimens of immunocompromised patients with pneumonia. The gram-negative isolates were susceptible to P-113. S. aureus showed less susceptibility. Synergy was demonstrated when P-113 was combined with beta-lactams against gram-negative organisms.

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