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Inducible Metronidazole Resistance and nim Genes in Clinical Bacteroides fragilis Group Isolates

Department of Laboratory Medicine, Division of Clinical Bacteriology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm,¹ Södertörns Högskola, Huddinge, Sweden²

Received 24 June 2004/ Returned for modification 11 September 2004/ Accepted 14 November 2004

Nitroimidazole resistance (nim) genes were detected in 2% of 1,502 clinical Bacteroides fragilis group strains isolated from 19 European countries, and a novel nim gene was identified. High metronidazole resistance could be induced in nim-positive strains, which emphasizes the importance of acknowledging metronidazole resistance in the clinical setting.

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