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Antimicrobial Agents and Chemotherapy, March 2005, p. 1253-1256, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1253-1256.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Inducible Metronidazole Resistance and nim Genes in Clinical Bacteroides fragilis Group Isolates

Sonja Löfmark,1,2 Hong Fang,1 Maria Hedberg,1 and Charlotta Edlund1,2*

Department of Laboratory Medicine, Division of Clinical Bacteriology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm,1 Södertörns Högskola, Huddinge, Sweden2

Received 24 June 2004/ Returned for modification 11 September 2004/ Accepted 14 November 2004

Nitroimidazole resistance (nim) genes were detected in 2% of 1,502 clinical Bacteroides fragilis group strains isolated from 19 European countries, and a novel nim gene was identified. High metronidazole resistance could be induced in nim-positive strains, which emphasizes the importance of acknowledging metronidazole resistance in the clinical setting.

* Corresponding author. Mailing address: Division of Clinical Bacteriology F 82, Huddinge University Hospital Huddinge, SE-141 86 Stockholm, Sweden. Phone: 46 8 58581139. Fax: 46 8 7113918. E-mail: charlotta.edlund{at}labmed.ki.se.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1253-1256, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1253-1256.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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