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Antimicrobial Agents and Chemotherapy, April 2005, p. 1553-1555, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1553-1555.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Molecular Mechanisms by Which rRNA Mutations Confer Resistance to Clindamycin

Jacob Poehlsgaard,1* Peter Pfister,2 Erik C. Böttger,2 and Stephen Douthwaite1

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark,1 Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland2

Received 7 October 2004/ Returned for modification 11 November 2004/ Accepted 10 December 2004

The mechanisms by which rRNA mutations confer clindamycin resistance were examined in Mycobacterium smegmatis strains containing homogeneous populations of ribosomes with base substitutions at nucleotides A2058 and A2059. Computer graphic predictions based on structural studies correlate with the resistance phenotypes for six of seven strains with unique rRNA mutations.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark. Phone: (45) 6550 2370. Fax: (45) 6550 2467. E-mail: jacobp{at}bmb.sdu.dk.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1553-1555, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1553-1555.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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