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Antimicrobial Agents and Chemotherapy, April 2005, p. 1556-1560, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1556-1560.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease

Milagros Corrales,1 Rubén Cardozo,1 María Asunción Segura,1 Julio A. Urbina,2* and Miguel Angel Basombrío1*

Laboratorio de Patología Experimental, Facultad de Ciencias de la Salud, Universidad Nacional de Salta, Buenos Aires, Salta, Argentina,1 Laboratorio de Quimica Biológica, Centro de Bioquimica y Biofisica, Instituto Venezolano de Investigaciones Cientificas, Carretera Panamericana, Caracas, Venezuela2

Received 23 October 2004/ Returned for modification 14 November 2004/ Accepted 14 December 2004

We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.

* Corresponding author. Mailing address for Julio A. Urbina: Laboratorio de Quimica Biológica, Centro de Bioquimica y Biofisica, Instituto Venezolano de Investigaciones Cientificas, Altos de Pipe, Km. 11, Carretera Panamericana, Caracas 1020, Venezuela. Phone: (58-212)-5041660. Fax: (58-212)-5041093. E-mail: jaurbina{at}ivic.ve. Mailing address for Miguel Angel Basombrío: Laboratorio de Patología Experimental, Facultad de Ciencias de la Salud, Universidad Nacional de Salta, Buenos Aires 177, 4.400 Salta, Argentina. Phone: (54-387)-4255333. Fax: (54-387)-4255333. E-mail: basombri{at}unsa.edu.ar.

* Corresponding author. Mailing address for Julio A. Urbina: Laboratorio de Quimica Biológica, Centro de Bioquimica y Biofisica, Instituto Venezolano de Investigaciones Cientificas, Altos de Pipe, Km. 11, Carretera Panamericana, Caracas 1020, Venezuela. Phone: (58-212)-5041660. Fax: (58-212)-5041093. E-mail: jaurbina{at}ivic.ve. Mailing address for Miguel Angel Basombrío: Laboratorio de Patología Experimental, Facultad de Ciencias de la Salud, Universidad Nacional de Salta, Buenos Aires 177, 4.400 Salta, Argentina. Phone: (54-387)-4255333. Fax: (54-387)-4255333. E-mail: basombri{at}unsa.edu.ar.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1556-1560, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1556-1560.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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