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Antimicrobial Agents and Chemotherapy, April 2005, p. 1567-1571, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1567-1571.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CTX-M-10 Linked to a Phage-Related Element Is Widely Disseminated among Enterobacteriaceae in a Spanish Hospital

Servicio de Microbiología, Hospital Universitario Son Dureta, Palma de Mallorca,¹ Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain²

Received 17 August 2004/ Returned for modification 22 November 2004/ Accepted 17 December 2004

CTX-M-10 has been widely disseminated among multiple clones of several species of Enterobacteriaceae, harboring seemingly different plasmids, for over a decade in Ramón y Cajal University Hospital, Madrid, Spain. Cloning and sequencing of a 12.2-kb DNA fragment from plasmid pRYCE21 from Klebsiella pneumoniae strain KP4aC revealed a novel phage-related element immediately upstream of bla_CTX-M-10 conserved among different CTX-M-10-producing strains. This is the first report showing an extended-spectrum-ß-lactamase gene linked to a phage-related element.

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