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Antimicrobial Agents and Chemotherapy, April 2005, p. 1580-1583, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1580-1583.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Early Selection of a New UL97 Mutant with a Severe Defect of Ganciclovir Phosphorylation after Valaciclovir Prophylaxis and Short-Term Ganciclovir Therapy in a Renal Transplant Recipient

Sébastien Hantz,1 Detlef Michel,2 Anne-Marie Fillet,3 Vincent Guigonis,4 Gaël Champier,1 Marie-Christine Mazeron,5 Albert Bensman,4 François Denis,1 Thomas Mertens,2 Axelle Dehee,6 and Sophie Alain1*

Department of Bacteriology-Virology-Hygiene, EA 3175, Teaching Hospital Dupuytren, Limoges,1 Department of Virology-CERVI, Teaching Hospital Pitié-Salpétrière,3 Department of Bacteriology-Virology-Hygiene, Teaching Hospital Lariboisière,5 Department of Pediatrics,4 Department of Virology, Teaching Hospital Trousseau, Paris, France,6 Abteilung Virologie, Institut für Mikrobiologie und Immunologie, Universitätsklinikum Ulm, Ulm, Germany2

Received 12 July 2004/ Returned for modification 20 September 2004/ Accepted 1 December 2004

We describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in ganciclovir resistance was supported by decreased ganciclovir phosphorylation in a recombinant vaccinia virus system.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie-Hygiène, CHRU Dupuytren, 2 ave. Martin Luther King, 87042 Limoges Cedex, France. Phone: 33 5 55 05 61 66/67 24. Fax: 33 5 55 05 67 24/22. E-mail: sophie.alain{at}unilim.fr.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1580-1583, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1580-1583.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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