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Antimicrobial Agents and Chemotherapy, April 2005, p. 1584-1586, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1584-1586.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Effects of Spectinomycin and Ceftriaxone Alone or in Combination with Other Antibiotics against Chlamydia trachomatis

Shuxian Shang,1 Longqing Xia,1 Mingying Zhong,1 Jinping Zhang,1 Jianbin Zhao,1 Xiangdong Gong,1 David Mabey,2 and Qianqiu Wang1*

National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China,1 Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, England2

Received 17 July 2004/ Returned for modification 20 July 2004/ Accepted 3 December 2004

The in vitro effects of spectinomycin and ceftriaxone, alone or in combination with erythromycin, ofloxacin, and doxycycline, against Chlamydia trachomatis were investigated by the checkerboard method and compared by Ridit (reference identical unit) analysis. A combination of spectinomycin with erythromycin or doxycycline was found to be more effective than that of ceftriaxone.

* Corresponding author. Mailing address: National Center for STD and Leprosy control, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China. Phone: 86-25-85478045. Fax: 86-25-85421323. E-mail: wangqianqiu{at}china.com.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1584-1586, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1584-1586.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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