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Antimicrobial Agents and Chemotherapy, April 2005, p. 1593-1596, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1593-1596.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Synergistic Activities of Fluconazole and Voriconazole with Terbinafine against Four Candida Species Determined by Checkerboard, Time-Kill, and Etest Methods

Emilia Cantón,1* Javier Pemán,2 Miguel Gobernado,2 Angel Viudes,2 and Ana Espinel-Ingroff3

Unidad de Microbiología Experimental-Centro de Investigación,1 Servicio de Microbiología, Hospital Universitario La Fe, Valencia, Spain,2 Division of Infectious Disease, VCU Medical Center, Richmond, Virginia3

Received 2 September 2004/ Returned for modification 8 October 2004/ Accepted 18 December 2004

The in vitro activities of fluconazole or voriconazole plus terbinafine were evaluated against 20 Candida isolates by the checkerboard, time-kill, and Etest methods. Synergism (C. albicans, C. glabrata, and C. tropicalis) and indifference (C. krusei) were observed. Correlation among methods was good. The Etest is a suitable method to determine drug interactions.

* Corresponding author. Mailing address: Unidad de Microbiología Experimental, Centro de Investigación, Hospital Universitario La Fe, Avenida Campanar 21, 46009 Valencia, Spain. Phone: 34 96 1973111. Fax: 34 96 1973018. E-mail: canton_emi{at}gva.es.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1593-1596, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1593-1596.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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