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Antimicrobial Agents and Chemotherapy, April 2005, p. 1608-1612, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1608-1612.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Cloning, Characterization, and Expression Analysis of Hepcidin Gene from Red Sea Bream (Chrysophrys major)

Song-Lin Chen,* Mei-Yu Xu, Xiang-Shan Ji, Guo-Cai Yu, and Yang Liu

Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Qingdao, People's Republic of China

Received 22 July 2004/ Returned for modification 13 October 2004/ Accepted 28 November 2004

A cDNA encoding hepcidin was isolated from a library of cDNA from spleen of red sea bream (Chrysophrys major) by expressed sequence tag analysis. The expression of the hepcidin mRNA in various tissues was examined. Challenge of red sea bream with Escherichia coli DH5{alpha} elevated hepcidin mRNA levels in spleen, gill, liver, and intestine.

* Corresponding author. Mailing address: Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Nanjing Road 106, 266071 Qingdao, People's Republic of China. Phone: 86-532-5844606. Fax: 86-532-5811514. E-mail: chensl{at}ysfri.ac.cn.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1608-1612, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1608-1612.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Xu, Q., Cheng, C.-H. C., Hu, P., Ye, H., Chen, Z., Cao, L., Chen, L., Shen, Y., Chen, L. (2008). Adaptive Evolution of Hepcidin Genes in Antarctic Notothenioid Fishes. Mol Biol Evol 25: 1099-1112 [Abstract] [Full Text]  


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