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Antimicrobial Agents and Chemotherapy, April 2005, p. 1613-1616, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1613-1616.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antibiotic Tolerance Induced by Lactoferrin in Clinical Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

María T. Andrés,1 Mónica Viejo-Diaz,1,2 Francisco Pérez,3 and José F. Fierro1,2*

Laboratory of Oral Microbiology, School of Stomatology,1 Department of Functional Biology (Microbiology), Faculty of Medicine, University of Oviedo,2 Department of Microbiology I, Central Hospital of Asturias, Oviedo, Spain3

Received 9 July 2004/ Returned for modification 26 September 2004/ Accepted 16 November 2004

Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated. This antibiotic tolerance effect (ATE) reflects the ability of a defense protein to modify the activity of an antibiotic as a result of its modulatory effect on bacterial physiology. P. aeruginosa isolates from cystic fibrosis patients showed higher ATE values (≤6-fold) than other clinical strains.

* Corresponding author. Mailing address: Department of Functional Biology (Microbiology), Faculty of Medicine, University of Oviedo C/Julian Claveria, 6, 33006 Oviedo, Spain. Phone: 34-985-103643. Fax: 34-985-103533. E-mail: jffierro{at}uniovi.es.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1613-1616, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1613-1616.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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