AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Newton, P. N.
Right arrow Articles by White, N. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Newton, P. N.
Right arrow Articles by White, N. J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2005, p. 1622-1625, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1622-1625.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Oral Doxycycline during Combination Treatment of Severe Falciparum Malaria

Paul N. Newton,1,2 Jean-François Chaulet,3 Alan Brockman,1,4 Wirongrong Chierakul,1 Arjen Dondorp,1,2 Ronatrai Ruangveerayuth,5 Sornchai Looareesuwan,1 Cyril Mounier,3 and Nicholas J. White1,2,4*

Shoklo Malaria Research Unit,4 Mae Sot Hospital, Mae Sot, Tak,5 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand,1 Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom,2 Laboratoire de biochimie, toxicologie et pharmacologie, Hopital d'Instruction des Armées Desgenettes, Lyon, France3

Received 24 June 2004/ Returned for modification 15 September 2004/ Accepted 3 December 2004

The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

* Corresponding author. Mailing address: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. Phone: (66) 2 354 9172. Fax: (66) 2 354 9169. E-mail: nickw{at}tropmedres.ac.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1622-1625, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1622-1625.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2005 by the American Society for Microbiology. All rights reserved.