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Antimicrobial Agents and Chemotherapy, April 2005, p. 1626-1628, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1626-1628.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Role of P-Glycoprotein in Distribution of Nelfinavir across the Blood-Mammary Tissue Barrier and Blood-Brain Barrier

Jeffrey E. Edwards,1 Jane Alcorn,2 Juoko Savolainen,3 Bradley D. Anderson,4 and Patrick J. McNamara4,5*

Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina,1 College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada,2 Department of Pharmaceutical Chemistry, University of Kuopio, Kuopio, Finland,3 Department of Pharmaceutical Sciences,4 Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky5

Received 29 June 2004/ Returned for modification 26 August 2004/ Accepted 1 December 2004

As a first approach in understanding the possible efficacy and toxicity of human immunodeficiency virus protease inhibitors during breast feeding, the milk-to-plasma ratio of nelfinavir was determined in lactating rats. The milk-to-plasma ratio of nelfinavir was determined to be 0.56 ± 0.10 (means ± standard deviations). Western blotting indicated that P-glycoprotein is expressed in rat mammary and brain tissue; however, the multidrug-resistant modulator GF120918 showed a significant effect only at the blood-brain barrier and not at the mammary-epithelial tissue barrier.

* Corresponding author. Mailing address: 907 Rose St., Room 327, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082. Phone: (859) 257-8656 Fax: (859) 257-7564. E-mail: pmcnamar{at}emmail.uky.edu.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1626-1628, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1626-1628.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Moeller, R. B. Jr., Puschner, B., Walker, R. L., Rocke, T. E., Smith, S. R., Cullor, J. S., Ardans, A. A. (2009). Short communication: Attempts to identify Clostridium botulinum toxin in milk from three experimentally intoxicated Holstein cows. J DAIRY SCI 92: 2529-2533 [Abstract] [Full Text]  
  • Wang, L., Leggas, M., Goswami, M., Empey, P. E., McNamara, P. J. (2008). N-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine Carboxamide (GF120918) As a Chemical ATP-Binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into Milk. Drug Metab. Dispos. 36: 2591-2596 [Abstract] [Full Text]  
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