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Antimicrobial Agents and Chemotherapy, April 2005, p. 1629-1632, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1629-1632.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Pharmacokinetic Profile of Tigecycline in Serum and Skin Blister Fluid of Healthy Subjects after Multiple Intravenous Administrations

Heather K. Sun,1 Christine T. Ong,1 Ambreen Umer,2 Dawn Harper,3 Steven Troy,3 Charles H. Nightingale,1 and David P. Nicolau1,4*

Center for Anti-Infective Research and Development,1 Division of Infectious Diseases, Hartford Hospital, Hartford,4 School of Medicine, University of Connecticut, Farmington, Connecticut,2 Wyeth Research, Collegeville, Pennsylvania3

Received 22 July 2004/ Returned for modification 9 November 2004/ Accepted 26 November 2004

The pharmacokinetics of tigecycline, when given as a 100-mg loading dose followed by 50 mg every 12 h, were determined in serum and blister fluid. The peak tigecycline concentration and half-life in serum were greater than those in blister fluid. Tigecycline penetrates into blister fluid well, with a mean penetration rate of 74%.

* Corresponding author. Mailing address: Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour St., Hartford, CT 06102. Phone: (860) 545-3941. Fax: (860) 545-3992. E-mail: dnicola{at}harthosp.org.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1629-1632, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1629-1632.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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