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Antimicrobial Agents and Chemotherapy, April 2005, p. 1633-1635, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1633-1635.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mutant Prevention Concentrations of ABT-492, Levofloxacin, Moxifloxacin, and Gatifloxacin against Three Common Respiratory Pathogens

Elizabeth D. Hermsen,1 Laurie B. Hovde,1 George N. Konstantinides,2 and John C. Rotschafer1*

College of Pharmacy, University of Minnesota, Minneapolis,1 Saint John's University, Collegeville, Minnesota2

Received 20 May 2004/ Returned for modification 15 September 2004/ Accepted 23 November 2004

The purpose of this study was to compare the mutant prevention concentration (MPC) of ABT-492 to those of levofloxacin, moxifloxacin, and gatifloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The fluoroquinolones had comparable mutation selection windows, which is the ratio of MPC/MIC, for all isolates.

* Corresponding author. Mailing address: College of Pharmacy, University of Minnesota, 9-157 WDH, 308 Harvard St. SE, Minneapolis, MN 55455. Phone: (612) 624-2183. Fax: (612) 625-1140. E-mail: rotsc001{at}umn.edu.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1633-1635, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1633-1635.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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