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Antimicrobial Agents and Chemotherapy, April 2005, p. 1636-1638, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1636-1638.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Presence of Tetracycline Resistance Determinants and Susceptibility to Tigecycline and Minocycline

Ad C. Fluit,* Alice Florijn, Jan Verhoef, and Dana Milatovic

Eijkman-Winkler Institute, University Medical Center Utrecht, Utrecht, The Netherlands

Received 5 August 2004/ Returned for modification 12 September 2004/ Accepted 16 December 2004

No relation between the presence of tetracycline resistance determinants tet(A) to tet(E) and the MICs of tigecycline was observed for Enterobacteriaceae, although tetracycline-susceptible isolates were more susceptible overall to tigecycline, whereas the presence of tet(M) in Staphylococcus aureus was associated with higher MICs of minocycline.

* Corresponding author. Mailing address: Eijkman-Winkler Institute, University Medical Center Utrecht, Room G04.614, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Phone: 31 30 2507630. Fax: 31 30 2541770. E-mail: A.C.Fluit{at}lab.azu.nl.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1636-1638, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1636-1638.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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