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Antimicrobial Agents and Chemotherapy, April 2005, p. 1639-1641, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1639-1641.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Functional Characterization of OXA-57, a Class D ß-Lactamase from Burkholderia pseudomallei

Karen E. Keith,¹ Petra C. Oyston,² Ben Crossett,¹ Neil F. Fairweather,¹ Richard W. Titball,² Timothy R. Walsh,³ and Katherine A. Brown^1*

Department of Biological Sciences, Centre for Molecular Microbiology and Infection, Imperial College London, London,¹ Dstl, Porton Down, Salisbury, Wiltshire,² Department of Pathology and Microbiology, University of Bristol, Bristol, United Kingdom³

Received 4 May 2004/ Returned for modification 15 July 2004/ Accepted 22 November 2004

Class D ß-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for ß-lactam resistance and the proposed role of Ser-104 in ß-lactam hydrolysis are discussed.

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* Corresponding author. Mailing address: Department of Biological Sciences, CMMI, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom. Phone: 44 20 75945298. Fax: 44 20 75945207. E-mail: k.brown{at}imperial.ac.uk.

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Antimicrobial Agents and Chemotherapy, April 2005, p. 1639-1641, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1639-1641.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

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