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Antimicrobial Agents and Chemotherapy, April 2005, p. 1646-1648, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1646-1648.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Genetic Basis of Antibiotic Resistance in Clinical Isolates of Streptococcus gallolyticus (Streptococcus bovis)

Roland Leclercq,^1* Corinne Huet,¹ Mélanie Picherot,² Patrick Trieu-Cuot,^2, and Claire Poyart^2,

Service de Microbiologie, CHU Côte de Nacre, Caen,¹ Laboratoire Mixte Pasteur Necker de Recherche sur les Streptocoques, Faculté de Médecine Necker, Paris, France²

Received 19 October 2004/ Returned for modification 18 November 2004/ Accepted 28 November 2004

Among 128 Streptococcus gallolyticus (Streptococcus bovis) isolates, 77.7% were resistant to tetracyclines and contained tet(M) and/or tet(L) and/or tet(O). A total of 59.4% had macrolide resistance and contained erm(B) and, rarely, mef(A). Among the one-third of isolates highly resistant to kanamycin and streptomycin, most harbored aphA3 and aad-6 genes.

Present address: Unité de Biologie des Bactéries Pathogènes à Gram Positif, Institut Pasteur, Paris Cedex 15, France.

Present address: Service de Bactériologie, CHU Cochin, Paris Cedex 14, France.

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