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Antimicrobial Agents and Chemotherapy, April 2005, p. 1656-1659, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1656-1659.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effects of Age and Sex on Single-Dose Pharmacokinetics of Tigecycline in Healthy Subjects

Gopal Muralidharan,1,{dagger} Richard J. Fruncillo,2 Marlynne Micalizzi,1 Donald G. Raible,1* and Steven M. Troy1

Wyeth Research, Collegeville,1 Wyeth Research Clinical Pharmacology Unit, Philadelphia, Pennsylvania2

Received 12 October 2004/ Returned for modification 29 November 2004/ Accepted 18 December 2004

The pharmacokinetics of tigecycline was evaluated in 46 healthy young and elderly men and women. Except for the volumes of distribution at steady state (approximately 350 liters in women versus 500 liters in men), there were no significant differences in tigecycline pharmacokinetic parameters. Based on pharmacokinetics, no dosage adjustment is warranted based on age or sex.

* Corresponding author. Mailing address: Department of Clinical Pharmacology Wyeth Research, 500 Arcola Rd., Collegeville, PA 19426. Phone: (484) 865-2519. Fax: (484) 865-9075. E-mail: RaibleD{at}wyeth.com.

{dagger} Present address: Lotus Labs Pvt. Ltd., Koramangala, Bangalore-560 095, India.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1656-1659, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1656-1659.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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