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Antimicrobial Agents and Chemotherapy, May 2005, p. 2095-2097, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2095-2097.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Spread of a Klebsiella pneumoniae Strain Producing a Plasmid- Mediated ACC-1 AmpC ß-Lactamase in a Teaching Hospital Admitting Disabled Patients

Salomon Ohana,¹ Veronique Leflon,² Esthel Ronco,¹ Martin Rottman,¹ Didier Guillemot,³ Sylvie Lortat-Jacob,⁴ Pierre Denys,⁴ Georges Loubert,⁵ Marie-Helène Nicolas-Chanoine,² Jean-Louis Gaillard,¹ and Christine Lawrence^1*

Laboratoire de microbiologie, Hôpital Raymond Poincaré, Assistance Publique—Hôpitaux de Paris, 92380 Garches, France,¹ Laboratoire de microbiologie, Hôpital Ambroise Paré, Assistance Publique—Hôpitaux de Paris, 92104 Boulogne, France,² Unité des agents antibactériens, Institut Pasteur, 75015 Paris, France,³ Département de médecine physique et réadaptation, Hôpital Raymond Poincaré, Assistance Publique—Hôpitaux de Paris, 92380 Garches, France,⁴ Département de réanimation chirurgicale, Hôpital Raymond Poincaré, Assistance Publique—Hôpitaux de Paris, 92380 Garches, France⁵

Received 7 September 2004/ Returned for modification 7 October 2004/ Accepted 12 January 2005

We describe a large outbreak involving a Klebsiella pneumoniae strain producing a plasmid-encoded ACC-1 type AmpC ß-lactamase in a hospital caring for patients with motor impairment. The epidemic strain was isolated from 57 patients in six wards between September 1999 and May 2003 and caused clinical infections in 19 patients.

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* Corresponding author. Mailing address: Laboratoire de microbiologie, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France. Phone: 33 1 47 10 77 25. Fax: 33 1 47 10 79 49. E-mail: christine.lawrence{at}rpc.ap-hop-paris.fr.

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Antimicrobial Agents and Chemotherapy, May 2005, p. 2095-2097, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2095-2097.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

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